Which of the following is NOT an adverse effect of acetaminophen?

Acetaminophen is generally well-tolerated and is not associated with gastrointestinal bleeding as an adverse effect. Unlike nonsteroidal anti-inflammatory drugs (NSAIDs), which can increase the risk of gastrointestinal issues, acetaminophen does not typically irritate the gastrointestinal tract or affect platelet function, making it a safer alternative for patients at risk of GI bleeding.

In contrast, toxic epidermal necrolysis, hepatotoxicity, and Stevens-Johnson syndrome are recognized adverse effects associated with acetaminophen use. Hepatotoxicity, in particular, can occur with overdose or chronic use, leading to liver damage. Toxic epidermal necrolysis and Stevens-Johnson syndrome, although rare, can occur as severe skin reactions. Understanding the specific side effects of medications, including their potential to cause gastrointestinal complications, is crucial for safe prescribing and patient management.