Which pharmacologic treatment is commonly used for chronic pain management?

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely utilized in the management of chronic pain due to their ability to effectively reduce inflammation and alleviate discomfort. They work by inhibiting the enzymes (COX-1 and COX-2) involved in the production of prostaglandins, substances in the body that mediate inflammation and pain. This mechanism makes NSAIDs particularly effective for conditions like arthritis and other inflammatory diseases, where pain is a significant component of the patient's experience.

Chronic pain management often requires a combination of treatment modalities, and while acetaminophen and corticosteroids can play a role, NSAIDs are generally favored for their dual-action of both pain relief and inflammation reduction. Herbal supplements, while potentially beneficial for some, lack the broad clinical validation and regulatory oversight that NSAIDs enjoy. This is why NSAIDs are a standard choice in both clinical practice and guidelines for treating chronic pain.